Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
Influence of Fluoride Contamination on Titanium Surface on Cell Viability and Cell Differentiation of ES-D3 Cells
Koichi IMAIMasayuki ZENNYUTakamitsu YOSHIDAYoshiaki ONOShunji KUMABETetsunari NISHIKAWA
ジャーナル フリー

2017 年 15 巻 1 号 p. 35-40


Developmental toxicity of chemical substances seriously impairs normal birth of human newborns. Corrosion resistance of titanium used in implant fixtures extremely decreases in the presence of fluorine ion produced by acidification. To our knowledge, cytotoxicity and developmental toxicity of corrosion products formed by corrosion of the titanium surface by fluoride have not been reported. Thus, we investigated differentiation and proliferation of ES-D3 cells, which is a parameter employed in the EST method. When the surfaces of JIS Class 1 and 2 titanium plates were corroded with hydrofluoric acid solution, cell differentiation and proliferation were affected. It was clarified that although this finding does not directly lead to clinical developmental toxicity, it is also necessary to investigate corrosion of titanium alloys used in implant fixtures.

© 2017 by Japanese Association of Regenerative Dentistry
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