Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ORIGINAL ARTICLES
IL-15, but Not IL-2, Induces Proliferative Activity of Human Ex Vivo Expanded Vγ9Vδ2 T Cells
Eisuke DOMAEKaname TSUJIYuya HIRAIYoshihiro YOSHIKAWAAiko KAMADAShosuke MORITASeiji GODATakashi IKEO
Author information
JOURNALS FREE ACCESS

2018 Volume 15 Issue 3 Pages 143-148

Details
Abstract

Human γδ T cells are subdivided into two main subsets, Vδ1 and Vδ2 T cells, based on the expression of the Vδ T cell receptor (TCR) subunit. Most peripheral blood γδ T cells express both Vδ2 and Vγ9 TCR subunits. Vγ9Vδ2 T cells are known to play a key role in immunity against microbial infection and tumors via recognition of non-peptide phospho-antigens. Here, we investigated the antigen-independent cytokine-dependent activation of ex vivo expanded Vγ9Vδ2 T cells. We found that IL-15, but not IL-2, induced cell division in ex vivo expanded Vγ9Vδ2 T cells in the absence of antigen stimulation.

Information related to the author
© 2018 by Japanese Association of Regenerative Dentistry
Previous article Next article
feedback
Top