Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Original Article
Effects of a Fish-Based Diet on the Serum Adiponectin Concentration in Young, Non-Obese, Healthy Japanese Subjects
Keiko KondoKatsutaro MorinoYoshihiko NishioMotoyuki KondoTomoya FukeSatoshi UgiHiromi IwakawaAtsunori KashiwagiHiroshi Maegawa
ジャーナル フリー

2010 年 17 巻 6 号 p. 628-637


Aim: Adiponectin has insulin-sensitizing, anti-atherogenic, and anti-inflammatory properties, and researchers have recently reported that ω-3 polyunsaturated fatty acid (PUFA) can increase the serum adiponectin concentration, suggesting that dietary factors, such as fish intake, may have an influence on the serum adiponectin concentration. In general, Japanese subjects consume twice as much fish as people in other countries. We hypothesized that incremental change in serum ω-3 PUFA levels by fish intake is an important regulator of serum adiponectin even in Japanese subjects. The aim of this study was to explore the relationship among fish consumption, serum ω-3 PUFA, such as eicosapentaenoic acid (EPA), levels, and serum adiponectin levels.
Method: We recruited 17 healthy Japanese volunteers (seven men and 10 women) for an 8-week fish-diet intervention (ω-3 PUFA 3.0 g/day) without affecting total energy intake, and measured serum adiponectin concentration and fatty acid profiles.
Results: Fish-diet intervention significantly increased the serum adiponectin concentration in women (from 13.5±4.6 to 15.8±5.2 µg/mL, p <0.01) but not in men (from 8.7±2.8 to 8.7±2.5 µg/mL). Serum ω-3 PUFA increased more in female subjects than male subjects after the fish-diet intervention (57.3±86.6 vs 150.9±46.7 µg/mL, p=0.011), suggesting that changes in ω-3 PUFA concentration may explain the different response between sexes.
Conclusion: A fish-based diet intervention increased the serum adiponectin concentration in young, non-obese, healthy Japanese female subjects. The increment in serum ω-3 PUFA may regulate the serum adiponectin concentration.


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