Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Original Article
Serum 25-Hydroxyvitamin D and the Incidence of Peripheral Artery Disease in the Elderly: The Pro.V.A Study
Nicola VeroneseMarina De RuiFrancesco BolzettaElena Debora ToffanelloAlessandra CoinSabina ZambonMaria Chiara CortiGiovannella BaggioEgle PerissinottoStefania MaggiGaetano CrepaldiEnzo ManzatoGiuseppe Sergi
Author information

2015 Volume 22 Issue 7 Pages 726-734


Aim: This study was conducted to examine whether low serum levels of 25-hydroxyvitamin D (25OHD)are associated with a higher risk of incident peripheral artery disease (PAD) in a representative group of elderly people.
Methods: We followed 1568 community-dwelling elderly participants without PAD at the baseline (among a sample of 2097 initially eligible) over a mean of 4.4 years as part of the Progetto Veneto Anziani (Pro.V.A.) study. The baseline serum 25OHD levels were categorized as <24, 25-49, 50-74, >75 nmol/L, and incident PAD was defined as an ankle-brachial index below 0.9.
Results: At the baseline, there were no differences in known risk factors for PAD (BMI, waist circumference, diabetes, cardiovascular diseases, smoking habits, total cholesterol) or in the ankle-brachial index (ABI) between the groups with different serum 25OHD levels (<24, 25-49, 50-74, >75 nmol/L). During a 4.4-year follow-up, 371 subjects developed PAD. The group with serum 25OHD levels >75 nmol/L was set as the reference group, and an adjusted Cox's regression analysis showed no association between low vitamin D levels and incident PAD during the follow-up: the hazard ratio ranged from 0.76 (95%CI: 0.41-1.42) for participants with serum 25OHD levels below 25 nmol/L to 1.32 (95%CI: 0.72-2.39) for those with serum 25OHD levels between 50-74 nmol/L (p for trend=0.08). These results did not change when participants were stratified by several risk factors for PAD.
Conclusions: Baseline hypovitaminosis D did not predict the onset of PAD over a 4.4-year follow-up in elderly people.

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