Journal of Atherosclerosis and Thrombosis
Original Articles
Influence of the Extent of Westernization of Lifestyle on the Progression of Preclinical Atherosclerosis in Japanese Subjects
Genshi EgusaHiroshi WatanabeKayo OhshitaRumi FujikawaKiminori YamaneMasamichi OkuboNobuoki Kohno
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Volume 9 (2002) Issue 6 Pages 299-304

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To clarify the influence of a westernized lifestyle on the risk factors for atherosclerosis and preclinical atherosclerosis in Japanese subjects, we surveyed a Japanese population and Japanese immigrants in the United States. Based on the extent of westernization of their lifestyle, the subjects were classified as Japanese (J), first generation Japanese-Americans (JA-I), and second or later generation Japanese-Americans (JA-II). The consumption of animal fat and simple carbohydrates increased in the order of J, JA-I, and J-II, while the subjects with strenuous physical activity decreased in the same order. The waist-hip ratio, fasting insulin level, serum cholesterol and triglyceride levels, and prevalence of hypertension increased in the same order as the dietary changes. The carotid intima-media wall thickness and the plaque size, which are indices of preclinical atherosclerosis, also increased in the order of J, JA-I, and JA-II. These data indicate that a westernized lifestyle aggravates the risk factors for atherosclerosis and influences the progression of preclinical atherosclerosis, in correspondence with the extent of westernization.

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