Thyroxine-Binding-Globulin (TBG) Deficiency and Hyperlipoproteinemia

Abstract

A kindred was presented in which 4 members in 3 generations showed absent or reduced serum concentrations of thyroxine-binding globulin (TBG). TBG was undetectable by radioimmunoassay in males and decreased in females. The mode of transmission of the trait was consistent with X-chromosome linkage.
Hyperlipoproteinemia was also present in 3 members with TBG abnormalities. Hyperlipoproteinemia was combination the type II and the type IV.
The mechanisms responsible for hyperlipoproteinemia in TBG abnormality remained obscure.