1982 年 10 巻 5 号 p. 981-988
1) There is a group of people in Japan who make it a habit of drinking a mixture of 3 egg yolkes and green tea (12g) (abbreviated as Egg Tea) which is one of folk remedies. We could get a chance of clinically examining 10 of these people (average year, 60) who had continued on this habit for quite many years (average 21 years). Their Tcho was 213.7mg/dl and T-G, 120.7mg/dl, which were both in their normal ranges. HDL-cho was 74.4mg/dl, atherogenic index (A. I) 2.0, which is low. Besides, their clinical results by ECG and chest XP examinations showed they were scarcely atherosclerotic.
2) In order to confirm the results of I-a), the egg tea was loaded for 3 months to stroke patients who had arrived at stable stage and their lipoprotein methabolism was examined, T-cho tended to rise in the first one month (In A Group who had egg tea 3 times a day, 38mg/dl), after which it reached a plateau and gradually declined. HDL-cho gradually rose (In A group, it revealed to 82mg/dl in the 2nd month) and the increase was dependent to the dose of administration and AT significantly declined in the 2nd month.
-b) Increase in ApoA concentration and LCAT activity was recognized.
-c) Loading of egg alone caused increase of T-cho and HDL-cho and a slight decline tendency of AI.
3) A long-term egg-tea loading coursed suppression of cholesterol synthesis, which worked more specifically strong on LDL-cho and VLDL-cho while HDL-cho was least suppressed. This suggests that in the cholesterol synthesis suppression mechanism the LDL system and HDL system are suppressed through different routes so that possible existence of two suppression pathways was suggested.
4) The fact that the long-time egg tea users had very few atherosclerotic symptoms clinically is considered due to suppression of LDL synthesis leaving HDL synthesis under less suppression so that its high value is maintained.