抄録
Daily 600mg of clinofibrate were administered to 28 patients with hyperlipidemia and the effect of the drug on serum lipoproteins and their apolipoproteins were investigated.
Serum total cholesterol, triglyceride, beta-lipoprotein, VLDL-LDL cholesterol and VLDL-LDL/HDL cholesterol ratio decreased significantly at 6 and 12 weeks after the drug administration. Serum HDL cholesterol increased at 6 and 12 weeks but apo A protein increased at only 12 weeks after. However, free fatty acid and free cholesterol were not affected by clinofibrate.
Percentage of alph-lipoprotein to total lipoprotein increased and that of pre beta-lipoprotein decreased reciprocally by the treatment. While, beta-lipoprotein ratio showed no significant change. The same tendency was observed in the profile of serum lipoprotein separated by ultra-centrifugation except slight decrease of beta-lipoprotein: the decrease of VLDL and the increase of HDL.
Every component of VLDL fraction decreased up to 60 per cent of the premedication levels by the treatment and triglyceride content in LDL fraction decreased markedly. Apoprotein, triglyceride and phospholipids in HDL fraction increased about 20 per cent of the pretreatment values.
Neither apo AI/AII and apo C ratio to total apoprotein in HDL nor composition of apo C protein in VLDL were affected by the drug administration. But apo E/C ratio in VLDL fraction showed the tendency to increase.
