Potentiation of Platelet Aggregation Induced by Several Kinds of Aggregating Agents

-Platelet aggregabilities induced by the mixture of epinephrine and collagen in healthy persons and patients with effort angina-

抄録

We observed platelet aggregation induced by several kinds of aggregating agents being both added to PRP. Furthermore, we compared platelet aggregabilities induced by a mixture of epinephrine and collagen between healthy persons and patients with effort angina.
ADP or collagen-induced platelet aggregations were potentiated by epinephrine. Weak potentiation by ADP and collagen was also found in platelet aggregation. Moreover, very strong potentiation of epinephrine, ADP and collagen was detected.
A lower concentration of the mixture of epinephrine and collagen caused more obvious platelet aggregation in patients with effort angina than in healthy persons.
The results in present experiments indicate that very low concentrations of aggregating agents can easily induce platelet aggregation by potentiation especially in patients with effort angina, because many aggregating agents are present in vessel bed and circulating blood.