Abstract
The clinical non-invasive methods for the differential and quantitative diagnosis of arteriosclerosis were developed in order to predict and to prevent the arteriosclerotic vascular diseases. The purpose of the study is to reveal the significance of the hyperlipoproteinemia in the progression of atherosclerosis in Japanese. The subjects of the study were 194 out- and in-patients, of whom 68 normolipidemics, 41 type IIa, 54 type IIb, and 31 type IV or V hyperlipoproteinemic patients were involved. All of them were examined about the severity of atherosclerosis expressed by the wall thickening and stenosis index (S. I.) and the calcification index (C. I.) of the lower abdominal aorta gotten from the computed tomography after or before the enhancement. The mid-band lipoprotein concentration was calculated from the mid-band ratio of the electrophoresis pattern of lipoproteins using 30% polyacrylamide gel and VLDL and LDL levels. Atherogenic index of lipids was obtained by the formula of (total cholesterol-HDL cholesterol)/HDL cholesterol.
The mid-band lipoprotein concentration was significantly correlated with atherogenic index. Both the mid-band lipoprotein and atherogenic index values were the highest in type IIb hyperlipoproteinemia and the lowest in normolipidemics. The mid-band lipoprotein also correlated with total cholesterol, triglyceride and HDL cholesterol, significantly. No significant correlation was observed between the mid-band lipoprotein and S. I., but atherogenic index inclined to be correlated with S. I. in fifth decade. Patients with type IIb and IV or V hyperlipoproteinemia tend to have more progression in S. I. than in C. I., on the contrary, type IIa inclined to C. I. Patients with hypertension and/or diabetes mellitus in addition to various types of hyperlipoproteinemia got higher value of S. I. and C. I. and turn to the direction of C. I. The mid-band lipoprotein in patients with effort type of coronary heart disease was 207.5mg/dl and higher than those in patients with vasospasm type of coronary heart disease. In progression of atherosclerosis, great differences were showed between male and female and by age. Analysis in larger populations should be required to avoid the influence of sex and age differences.
