Changes of Lipoprotein Levels during Insulin Infusion in Familial Hypercholesterolemia IIa

Abstract

Serum cholesterol and Apo B significantly decreased during 2 hours of insulin infusion in normal and diabetic subjects, but not in heterozygous FH who only have 50% of LDL receptor activity. Cholesterol in VLDL+IDL & LDL fractions also decreased in diabetic subjects, but no significant change was observed in FH. The result indicate that insulin has an early stimulating effect for LDL pathway.