Abstract
In order to observe the effects of milk administration on serum lipoprotein levels in newborns, serum lipids and apolipoproteins (apo A-I, A-II, A-IV, B, C-II, C-III and E) were determined successively in the early neonatal period. Levels of apo A-I, A-IV, B, C-II and C-III significantly increased during the period compared to the initial levels at birth. In particular, apo A-IV level significantly increased from 6.9±1.0mg/dl on day 0 to 8.1±1.6 (p<0.05) and 15.7±2.8mg/dl (p<0.001) on day 3 and 6, respectively. Serum apo A-I also increased during the period, though it did not change markedly compared to apo A-IV. Although apo B level significantly increased during the period, it is unclear which of the apo B species, apo B-48 or B-100, is more responsible for the increase in the present study. Conversely, apo A-II and E levels did not change significantly during the period. Apo A-IV increased most markedly during the period compared to those of other apolipoproteins determined in this study, suggesting that the production of apo A-IV in the intestine was increased considerably during fat absorption by the lactation.
