Abstract
The influences of nitrites (pentaerythritol tetranitrate PETN) and dipyridamole on the myocardial tissue oxygen tension were determined in five anesthetized open chest dogs using polarographic method.
The results obtained were as follows;
1. Administration of PETN (2mg/Kg) caused evident elevation of tissue oxygen tension in the subendocardium, simultaneously the evident decrease in left ventricular endodiastolic pressure (LVEDP) was observed.
2. Administration of dipyridamole (0.3mg/Kg) caused consistent increase of mycoardial oxygen tension in subendocardium, while no constant response in subepicardium.
It was considered that the elevation in subendocardial tissue oxygen tension after administration of PETN was induced by the decrease in the preload (LVEDP).
