Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
A New Approach for the Detection of Type III Hyperlipoproteinemia by RLP-Cholesterol Assay
Katsuyuki NakajimaToshimitsu SaitoAki TamuraMotoko SuzukiTakamitsu NakanoMasakazu AdachiAkira TanakaNorio TadaHaruo NakamuraToshio Murase
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1994 Volume 1 Issue 1 Pages 30-36

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Abstract

Type III is a remnant hyperlipoproteinemia identified by the presence of β-VLDL (remnant lipoprotein) as well as a genetic variant of apo E (apo E2/2). The RLP isolated from the serum of Type III patients by a new method we have developed, the RLPcholesterol assay, was identified as chylomicron and VLDL remnant. In addition, the RLP-C levels of the Type III patients were significantly higher than other hyperlipidemic patients with similar serum TG levels, while the ratio of TC/TG in RLP-C of both groups was not significantly different. The RLP-cholesterol assay appears to be useful for the screening and monitoring of Type III hyperlipoproteinemia when used in conjunction with the assays of serum TG level and genetic apo E isoform analysis.

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