Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Simvastatin, a potent HMG-CoA Reductase Inhibitor, inhibits the Proliferation of Human and Bovine Endothelial Cells in vitro
Ikuko SatoLijuan MaMasayuki IkedaIkuo MoritaSei-itsu Murota
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1998 Volume 4 Issue 3 Pages 102-106


We investigated in vitro effect of simvastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the proliferation of human and bovine endothelial cells (EC) compared to that of bovine smooth muscle cells (SMC). Cells were cultured in a medium supplemented with 10% normal serum (FBS). Simvastatin at concentrations ranging from 0.1 μg/ml to 10 μg/ml were used. In each kind of cells the proliferation was markedly reduced at 1 μg/ml of simvastatin (P<0.01) which was accompanied by morphological changes in the cell shape. We conclude that simvastatin inhibits the proliferation of not only the smooth muscle cells but also the endothelial cells.

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