An Inhibitor of VCAM-1 Expression and Its Implication as a Novel Treatment of Inflammatory Diseases

抄録

To evaluate endothelial-leukocyte adhesion, we developed an adhesion technique using human umbilical vein endothelial cells (HUVECs) and U-937 cells. This technique clarified that ICAM-1 and VCAM-1 were primarily responsible for this adhesion. Using this technique, we found a low molecular weight compound that potently inhibits the adhesion through specifically suppressing the expression of VCAM-1 of HUVECs. When orally administered to mice, this compound also diminished the increase in paw thickness and in anti-bovine type II collagen (anti-BII) antibodies in mouse collagen-induced arthritis.