Acute Pancreatitis and Hyperchylomicronetnia

抄録

Hyperchylomicronemia is known to lead a life-threatening acute pancreatitis. The major metabolic basis is a deficiency of lipoprotein lipase or apolipoprotein C-II, both of which play a critical role in the metabolism of triglyceride-rich lipoproteins. We presented two secondary chylomicronemic cases : One was already published elsewhere as autoimmune hyperchylomicronemia, in which several episodes of acute pancreatitis were demonstrated. The other was a case of unknown origin, in which both lipoprotein lipase and apolipoprotein C-II were preserved. The case had no history of acute pancreatitis, although it demonstrated coronary heart disease and atherosclerotic major artery disease. From these observation, we speculated cases with no abnormality of lipoprotein lipase or apolipoprotein C-II are less frequently suffered from acute pancreatitis, especially in Japan where fat consumption is less than that in western country.