実験的石灰化 -Mastocalcergy-における肥満細胞の役割

抄録

Experimental calcification called ‘mastocalcergy’ was elicited in mice. Each mouse was injected with 1.0mg of lead acetate intra-venously followed by subcutaneonu injection of 0.5mg of compound 48/80 (a mast cell discharger). It is generally believed that mast cells play an essential role in ‘mastocalcergy’. We used mast-cell-deficient W/W^v mice in order to evaluate the role of mast cells in this form of calcification. Despite the deficiency of mast cells, the amount of calcification in W/W^v mice was comparable with that in normal congeneic mice. Therefore, it can be concluded that mast cells are not necessarily essential in ‘mastocalcergy’.