Feasibility analysis of no tumorigenicity potential stem cells therapy for central nervous system injury

抄録

Central nervous system (CNS) injuries lead to severe and permanent neurological deficits. Fortunately, as a result of the rapid progress in biomedical science, particularly the stem cell biology, stem cell transplantation holds promise for promoting anatomical repair and functional recovery after traumatic or ischemic injuries to the CNS. However, the tumorigenic potential of these cells remains a great concern, as reflected in the formation of teratomas by transplanted pluripotent cells. This gap in the field is particularly serious as stem cell tumori-genicity represents the key obstacle to the safe use of stem cell-based therapy for CNS injuries. Although some adult stem cell therapies appear to be safe, they have only a very narrow range of uses in human disease. In this review, the links between pluripotency and tumorigenicity are explored. And new medical imaging modalities for more accurately testing the tumorigenic potential of iPSC and of other stem cells applicable to regenerative medicine are proposed. Finally, the most promising emerging approaches for overcoming the challenges of stem cell tumorigenicity are highlighted.