2017 年 12 巻 4 号 p. 17-00189
Mechanisms of development, growth, and rupture of a cerebral aneurysm have been studied by computational fluid dynamics (CFD), calculating hemodynamic parameters, such as wall shear stress, oscillatory shear index (OSI), and relative residence time (RRT). It is well known that the upstream velocity profile and upstream vessel shape influence the computational results. However, few studies have dealt with cases involving a bifurcation upstream of a cerebral aneurysm. Furthermore, the fluid-dynamic effects of multiple structural elements of upstream vessel shape, such as a bifurcation and a bend, on the results of CFD remain unknown. The purpose of this study was to elucidate the fluid-dynamic effects of multiple structural elements of upstream vessel shape such as bifurcation and bend on blood flow and hemodynamic parameters inside an aneurysm. Computations were performed for blood flow in a cerebral aneurysm with upstream sequential elements of a bifurcation, a bend, and a straight section, using four models with different upstream boundaries, i.e., before the bifurcation, after the bifurcation before the bend, after the bend, and after the straight section just before the cerebral aneurysm. The results were compared to elucidate the effect of each upstream structural element on the blood flow and hemodynamic parameters in the cerebral aneurysm. Differences in OSI and RRT resulting from changes in the velocity distribution were observed locally in the aneurysm between the models. It was also found that the effect of the bifurcation on the velocity distribution was greater than that of the bend.