Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Original Articles
Fasting Differentially Modulates the Immunological System: Its Mechanism and Sex Difference
Keiichi HiramotoTamami HommaMika JikumaruHirohisa MiyashitaEisuke F. SatoMasayasu Inoue
著者情報
ジャーナル フリー

2008 年 43 巻 2 号 p. 75-81

詳細
抄録

The immunological properties and hormonal metabolism in rodents are affected by physical and psychological stress more strongly in males than in females. To elucidate the mechanism and physiological significance of the sex difference in the susceptibility of animal to stresses, changes in the immunological system in plasma and intestine and hormonal status in plasma were compared among 8-week-old male and female ICR mice before and after fasting. During the fasting of animals, the expression of immunoglobulin A in intestinal mucosa, and cortisol, interleukin-10 and interferon-γ in plasma increased. These changes occurred more apparently in males than in females. Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary. These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.

著者関連情報
© 2008 by The Editorial Secretariat of JCBN
前の記事 次の記事
feedback
Top