Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Effects of TJ-35 (Shigyaku-san) on Gastric Mucosal Injury Induced by Ischemia-Reperfusion and Its Oxygen-Derived Free Radical-Scavenging Activities
Toshikazu YOSHIKAWAShuji TAKAHASHIHiroshi ICHIKAWAHirohisa TAKANONaohiro TASAKIMitsunori YASUDAYuji NAITOToru TANIGAWAMotoharu RONDO
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1991 年 10 巻 3 号 p. 189-196

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We investigated the effects of TJ-35 (Shigyaku-san) on gastric mucosal injury induced by ischemia-reperfusion in rats; and using the electron spin resonance (ESR) spin trapping method, we also assessed its oxygen-derived free radical-scavenging activities. The increase in mucosal lesions and in thiobarbituric acid-reactive substances (as an index of lipid peroxidation) was significantly inhibited by the oral administration of 500mg/kg of TJ-35; and in addition, TJ-35 demonstrated superoxide and hydroxyl radical-scavenging activities in vitro. These results suggest the possibility that the effects of TJ-35 on gastric mucosal injury induced by ischemia-reperfusion may be the result of its free radical-scavenging activities.

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