1992 年 12 巻 3 号 p. 193-199
The inhibitory effect of γ-Oryzanol on liver cirrhosis induced by a high-fat diet in spontaneously hypertensive rats (SHRs) was investigated. Eight-week-old SHRs were fed a high-fat diet or a high-fat diet with γ-Oryzanol for 3 months, Lipogenic liver cirrhosis was induced in the animals fed the high-fat diet only. In contrast, supplementation of the diet with γ-Oryzanol suppressed liver cirrhosis and hyperlipidemia in the supplemented group. This study suggests that γ-Oryzanol is very effective against lipogenic liver cirrhosis in the SHR, an animal which possesses natural abnormalities in lipid metabolism.