Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Trypanocidal Activity of an Organotin Compound (Tri-n-Butyltin Oxide) toward Trypanosoma brucei
Andrew J. NOKKing A.N. ESIEVOAdaudi ARMBROSEAchoba I. ISAACGimba C. EMMANUELMusa O. SOLOMONKagbu A. JAMES
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1992 Volume 13 Issue 2 Pages 81-85

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Abstract

The organotin compound Tri-n-butyltin oxide was found to possess trypanocidal activity against Trypanosoma brucei. In vitro studies with the drug at 200μg/ml immobilized and lysed the parasites. In vivo experiments in infected rats at a dosage of 10mg/kg/day for 4 consecutive days completely cleared the blood of the parasites. Pathological analysis of the brains, kidneys, and livers of the treated animals did not reveal any abnormalities 6 weeks post-treatment. However, parasite-altered kidney Na+, K+-ATPase kinetics was observed to be rectified post-treatment.

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