1995 年 19 巻 3 号 p. 131-136
Ascorbic acid has been reported to have corrective influences on the alteration of metabolic processes observed during ageing. We determined the effect of ascorbic acid supplementation (20mg/100g body weight) for 15, 30, and 60 days on young and aged rats. Organ weight and ascorbic acid content of the liver, spleen, and kidney as well as their deoxyribonucleic acid and ribonucleic acid contents were low in aged rats, although a considerable increase in the values of these parameters was noted after supplementation with ascorbic acid; and for 30 days the magnitude of the increase rose further after supplementation for 60 days. The organ weights and ascorbic acid and nucleic acid contents increased markedly only on prolonged ascorbic acid supplementation (i.e., 60 days) in young rats.