Influence of Gallic Acid and Propylgallate on Antioxidant Defense Systems and Lipid Peroxidation in Mice
1997 年 22 巻 3 号 p. 155-161
詳細
1997 年 22 巻 3 号 p. 155-161
Feeding of gallic acid elevated the hepatic levels of glutathione peroxidase (GPx) and catalase, whereas NADPH-mediated microsomal lipid peroxidation was found to be unaltered. However, in lungs, besides a significant increase in reduced glutathione (GSH) and GPx, there was an inhibition of enzymatic lipid peroxidation in post-mitochondrial supernatant. On the other hand, propylgallate increased the hepatic GPx and GSH as well as inhibited hepatic microsomal and pulmonary lipid peroxidation. It seems that propylgallate is a better antioxidant than gallic acid since unlike gallic acid it protects both liver and lungs from the damaging action of the free radical-mediated process of lipid peroxidation.
