Effects of Mazindol on the Hyperglycemia Induced by Intracranial Injection of 2-Deoxy-D-Glucose or by Oral Glucose Load in Intact and Diabetic Rats

抄録

We previously found that mazindol reduces food efficiency [=increase in body weight (g) per day/food intake (g) per day] in rats (Nagai et al., J Obesity Weight Regul., 4, 33-49, 1985). In order to elucidate the action of mazindol with respect to food efficiency, the effects of its administration on the elevation of the blood glucose concentration induced by Intracranial injection of 2-deoxy-D-glucose (2DG) into intact rats, or by the imposition of an oral glucose load in intact and diabetic rats, were examined. We observed that peripheral, but not central, administration of mazindol inhibited the hyperglycemia elicited by 2DG injection and enhanced glucose tolerance following an oral glucose load in diabetic rats, but not intact animals. These findings suggest that peripheral administration of mazindol reduces the blood glucose concentration when it is elevated. Therefore, it is possible that the reductive effect of mazindol on food efficiency might be induced by the enhancement of glucose uptake into cells of tissues such as skeletal muscle, since our previous work suggested that mazindol increases glucose uptake into skeletal muscle cells (Nagai et al., Eur. J. Pharmacol., 260, 29-37, 1994),