Effect of Cynodon dactylon and Tenoxicam on the Lysosomal Enzyme Activities in the Cartilage Tissue of Osteoarthritic Guinea Pigs

抄録

To estimate the chondroprotective effect of Cynodon dactylon, an indigenous drug, we measured the activities of lysosomal enzymes, β-glucuronidase, N-acetyl-β-D-glucosaminidase, and cathepsin D in cartilage tissues of guinea pigs with experimentally induced osteoarthritis (OA). Induction of OA was achieved by intra-articular injections of papain into the knee joints of guinea pigs. OA-induced animals were treated with either Cynodon dactylon, an indigenous drug, or tenoxicam, a known chondroprotective allopathy drug. The result showed that the activities of the lysosomal enzymes were increased in the cartilage tissue of OA-induced animals and that these values were reversed to normal by both of the interventional agents. The reason for this normalcy may be attributed to the anti-inflammatory effect of the drugs, probably due to stabilization of the lysosomal membrane.