N-Acetyl Cysteine in Combination with Vitamin C Enhances the Antioxidant Status of a Lung Carcinoma Cell Line in Vitro
1999 年 26 巻 1 号 p. 1-8
詳細
1999 年 26 巻 1 号 p. 1-8
The present study was carried out to evaluate the effect of N-acetyl cysteine and vitamin C on a lung carcinoma cell line. We studied the trypan blue exclusion pattern of a malignant lung cell line, NCI-H82, with and without supplementation of the drugs added alone or in combination. The levels of lipid peroxidation and glutathione were estimated in addition to the estimation of antioxidant enzymes. The results suggested the antiproliferative nature of the drugs, the effect being more when the drugs were added in combination. Both of the drugs could elevate the level of glutathione in lung cancer cells and the activities of antioxidant enzymes, thus minimizing the cancer-promoting, peroxidative damage to the cells.
