Formation of Lipid-Laden Cells from Cultured Aortic Smooth Muscle Cells and Macrophages by Linoleic Acid Hydroperoxide and Low Density Lipoprotein

抄録

When cultured aortic smooth muscle cells were incubated with linoleic acid hydroperoxide and then with low density lipoprotein, marked deposition of lipids in the cells, viz., formation of lipid-laden cells, occurred; while incubation with either linoleic acid hydroperoxide alone or low density lipoprotein alone scarcely provoked the deposition of lipids in the cells. In the case of macrophages derived from monocytes, their incubation with low density lipoprotein preincubated with linoleic acid hydroperoxide resulted in formation of typical lipid-laden cells, even though incubation of the cells with either linoleic acid hydroperoxide alone or intact low density lipoprotein alone scarcely produced lipid-laden cells.