Possible Involvement of Iron-Dependent Lipid Peroxidation in the Delayed Neuronal Death of Rat Brain after a Transient Ischemia

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Lipid peroxide levels in rat hippocampus and cortex were determined at 6, 24, and 48h following ischemia for a period of 20min. A significant (p<0.05) but transient increase in lipid peroxide formation was found in the hippocampus at 24h following ischemia. Regional iron concentration determined by inductively coupled plasma (ICP) emission spectrometry revealed that the concentration of iron in the hippocampus was also significantly elevated at 24h following ischemia, suggesting that in the hippocampus the increase in the concentration of iron resulted in promotion of lipid peroxidation. Though lipid peroxide and iron levels were reversed at 48h following ischemia, iron-dependent lipid peroxidation was possibly involved in the onset of delayed neuronal death in the rat hippocampus.