Effect of Oral Administration of Dextran Sulfate on Endogenous Plasma Lipoprotein Lipase and Hepatic Lipase Activities in Healthy Men
1988 年 5 巻 1 号 p. 59-66
詳細
1988 年 5 巻 1 号 p. 59-66
We examined whether or not endogenous plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities are stimulated by oral administration of dextran sulfate (DS). The diurnal fluctuations of the plasma activities of the lipases were studied together with the diurnal profiles of triglyceride in chylomicrons and in very low density lipoprotein (Chyl-VLDL-TG), and apoproteins (C-II, C-III, and E) in 8 young healthy men during the administration of a test diet and during the administration of the test diet combined with a total daily dosage of 1, 800mg of DS.
Chyl-VLDL-TG decreased before supper and the decrease was more marked in the DS group than in the control group. The diurnal plasma apoproteins C-II, C-III, and E showed a gradual but significant reduction when DS was not given, but the levels did not decrease when DS was administered. In the control group, the LPL activity showed only a minute fluctuation which was characterized by an insignificant increase after each meal. In the DS group, on the other hand, the LPL activity showed a stepwise increase, and the activity before supper (27.5±6.6nmol FFA/ml/h, M±SE) was significantly greater (p<0.05) than the activity in the fasting plasma (8.3±1.4nmol FFA/ml/h). In contrast, the HL activity did not show any significant fluctuation in either group. Only the HL activity at 12 noon in the DS group (17.4±5.5nmol FFA/ml/h) tended to be greater than the activity at 8a.m. (8.8±1.8nmol FFA/ml/h).
Thus, the oral administration of DS was shown to promote the diurnal Chyl-VLDL-TG clearing in healthy men by stimulating the release of LPL into circulation and by maintaining the LPL co-factors such as apoproteins C-II, C-III, and E.
