Effects of Local Hyperthermia Treatment on Skin SOD Activity in Mice

抄録

The effect of local hyperthermia treatment (43°C, 45min) on normal mouse skin was studied by examining superoxide dismutase (SOD) activity and histology of the skin. SOD activity of the skin decreased significantly 1, 4, 7, and 14 days after the treatment. The decrease reached a peak 4 days after the treatment and recovered to some extent by 14 days after the treatment. The decrease in SOD activity may be due to consumption of SOD by inflammation as well as to the destruction of SOD by hyperthermia. Histological examination of hyperthermia-treated skin showed edema, bleeding, and inflammatory cell infiltration in the dermis, and individual cell keratinization and acanthosis in the epidermis. It is important to estimate the decrease in SOD activity and tissue injury of the skin by hyperthermia in order to use hyperthermia more effectively with fewer side effects.