Effects of Lidocaine on Cerebral Metabolic Changes during Forebrain Ischemia Analyzed by in vivo ³¹P-NMR Spectroscopy

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The effects of lidocaine on cerebral metabolic changes during and after forebrain Ischemia (10min) in a rat model were studied by in vivo ³¹P-NMR spectroscopy. Rat brains were made ischemic for 10min by bleeding to 40mmHg with subsequent application of bilateral carotid artery occlusion. Forebrain Ischemia caused a decrease in intracellular high-energy phosphates and in intracellular pH (pH_i) in both control and lidocaine-treated groups, but its extent was smaller in the lidocaine-treated group than in the control group. Moreover, lidocainetreated group showed a faster return to the preischemia level in cerebral energy metabolism than the control group after forebrain ischemia. Thus, lidocaine was shown by ³¹P-NMR spectroscopy to have a protective effect, particularly in relation to cerebral high-energy phosphates.