Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Electron Spin Resonance Study on Lipopolysaccharide-Induced Membrane Damage in Erythrocytes
Yuji HINO, Ryukichi KUMASHIRO, Takaomi HAMADA, Yuriko KOGA, Hitoshi NAKANO, Hirohiko ABE, Michio SATA, Hiroshi UEDA, Ryohei OGURA, Kyuichi TANIKAWA
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キーワード: lipopolysaccharide (LPS), electron spin resonance (ESR), membrane fluidity, Na+, K+-ATPase, hydroxy radicals
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1990 年 9 巻 3 号 p. 143-150

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The interaction between lipopolysaccharide (LPS) and rat erythrocyte membranes was studied in vitro. The incubation of erythrocytes with LPS isolated from E. coli (J5 mutant) resulted in a decrease in membrane fluidity as determined by spin-label, electron spin resonance, and in the inhibition of Na+, K+-ATPase activity without remarkable alteration of the membrane lipid composition. The generation of hydroxy radicals was detected by spin-trap, electron spin resonance in the erythrocyte/LPS incubation medium. We suggest that changes in the dynamic properties of erythrocyte membranes were mediated by LPS itself and not indirectly by changes in the membrane lipid composition.

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