2018 Volume 17 Issue 1 Pages 57-64
Various protein molecules concert with each other to express diverse biological functions. Because these multicomponent biological molecules weakly interact with each other, they can undergo regulatory dissociation and association upon inducing biological stimuli. In order to understand biological systems, we must, at first, aim to identify every possible unstable complex involved in the given multicomponent system, and then quantitatively analyze the interactions of these complex molecules. However, because of the complexity, it is generally difficult to apply conventional analytical methods to analyze such multi-component equilibrium systems. We have developed a new analytical device that would enable us to perform structure and interaction analyses on multi-component equilibrium systems. Here, I would like to introduce the description of the device and its potential applications of this sampling system applied for continuous titration SAXS method.
