Print ISSN : 0021-9592
Micro and Nano Systems
Design of a Flow Reactor System for Safe Handling of Phosgenation Reactions: Scale-Up Study of T-Shaped Mixers for Industrial Chemical Production
Tomoyuki ToyodaShiori OzasaTakahiro Ohishi
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2019 Volume 52 Issue 9 Pages 773-777


Process safety of hazardous phosgenation reactions during industrial chemical production is a critical issue. We herein have designed a compact flow reaction process for phosgenation reactions and successfully installed the system at a commercial plant. The hold-up of phosgene was significantly reduced and a leakage detecting system was incorporated in the commercial process. A scale-up method for determining the mixing condition of the commercial-scale flow reactor was the most important task in this study. The Villermaux–Dushman reaction was employed to evaluate the mixing performance of the T-shaped mixers with the mixer outlet diameter, Dm ranging from 0.5×10−3 to 15.0×10−3 m. The scale-up condition was determined by the absorbance of the Villermaux–Dushman reaction solution. Utilizing the experimental results, a diagram of the mixing performance in terms of Dm and the flow rate was obtained. It was found that the fluid segment size Wc (=Dm/20.5) in a T-shaped mixer, and the Reynolds number of the mixer flow Re are important parameters for mixing in the T-shaped mixers. We derived the correlation between the mixing performance and Wc/Ren. It was found that all of the mixers utilized in this study had the same correlation with an n value of 1.19. We also confirmed that the derived equation is applicable for scaling up the T-shaped mixers.

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© 2019 The Society of Chemical Engineers, Japan
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