Journal of Chemical Software
Online ISSN : 1883-8359
Print ISSN : 0918-0761
ISSN-L : 0918-0761
Introduction of Physicochemical PropertiesTermed Stickiness and Pseudostickiness to Quantification of Macromolecule-interaction and Its Application to the Analysis of Lambda Genome DNA
Koichi NISHIGAKIYoshito SAKUMA
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JOURNALS FREE ACCESS

1994 Volume 2 Issue 2 Pages 96-107

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Abstract

A new quantity, stickiness, was proposed that enables us to deal quantitatively with interactions between a macromolecule (e.g., DNA) and a ligand (e.g., oligonucleotide) and gives an image of global/local effects in molecular interactions.Pseudostickiness, its manageable version based on binding constant, was calculated and applied to an analysis of lambda DNA sequence, revealing some characteristics of the lambda genome. The utility of stickiness in understanding specific interactions of biomolecules is also discussed.

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