Hypertrophic Cardiomyopathy With Type I CD36 Deficiency

Kenichi Watanabe; Ken Toba; Yusuke Ogawa; Makoto Kodama; Satoru Hirono; Yuji Ohkura; Haruo Hanawa; Yuichi Nakamura; Yoshinori Aoki; Ichiro Fuse; Yoshifusa Aizawa; Seiichi Miyajima; Yoriko Kusano; Takafumi Nagatomo; Go Hasegawa; Makoto Naito

doi:10.1253/jcj.62.541

Case Report

Hypertrophic Cardiomyopathy With Type I CD36 Deficiency

Kenichi Watanabe, Ken Toba, Yusuke Ogawa, Makoto Kodama, Satoru Hirono, Yuji Ohkura, Haruo Hanawa, Yuichi Nakamura, Yoshinori Aoki, Ichiro Fuse, Yoshifusa Aizawa, Seiichi Miyajima, Yoriko Kusano, Takafumi Nagatomo, Go Hasegawa, Makoto Naito

Author information

Kenichi Watanabe
Clinical Pharmacology, Niigata College of Pharmacy
Ken Toba
First Department of Medicine, Niigata University School of Medicine
Yusuke Ogawa
First Department of Medicine, Niigata University School of Medicine
Makoto Kodama
First Department of Medicine, Niigata University School of Medicine
Satoru Hirono
First Department of Medicine, Niigata University School of Medicine
Yuji Ohkura
First Department of Medicine, Niigata University School of Medicine
Haruo Hanawa
First Department of Medicine, Niigata University School of Medicine
Yuichi Nakamura
First Department of Medicine, Niigata University School of Medicine
Yoshinori Aoki
First Department of Medicine, Niigata University School of Medicine
Ichiro Fuse
First Department of Medicine, Niigata University School of Medicine
Yoshifusa Aizawa
First Department of Medicine, Niigata University School of Medicine
Seiichi Miyajima
Division of Cardiology, Tsubame Rousai Hospital
Yoriko Kusano
Division of Cardiology, Tsubame Rousai Hospital
Takafumi Nagatomo
Pharmacology, Niigata College of Pharmacy
Go Hasegawa
Second Department of Pathology, Niigata University School of Medicine
Makoto Naito
Second Department of Pathology, Niigata University School of Medicine

Keywords: CD36 deficiency, endothelial cell, hypertrophic cardiomyopathy, ¹²³I-BMIPP, long-chain fatty acid

JOURNAL FREE ACCESS

1998 Volume 62 Issue 7 Pages 541-542

DOI https://doi.org/10.1253/jcj.62.541

Details

Abstract

CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). A patient presented with hereditary hypertrophic cardiomyopathy (HCM) and type I CD36 deficiency (neither platelets nor monocytes expressed CD36) but showed no myocardial LCFA accumulation. CD36 was expressed in the capillary endothelial cells of the cardiac muscle of a control subject, while the patient's myocardial capillary endothelial cells were completely CD36-negative. These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation. (Jpn Circ J 1998; 62: 541 - 542)

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