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JAPANESE CIRCULATION JOURNAL
Vol. 65 (2001) No. 2 P 81-86

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http://doi.org/10.1253/jcj.65.81

Clinical Investigation

It has been reported that coronary endothelial dysfunction is associated with the pathogenesis of coronary spasm, and that endothelial nitric oxide (NO) mediated vasodilatation was decreased in coronary epicardial arteries in patients with coronary spastic angina (CSA). However, there are few reports about the endothelial function in peripheral resistance vessels of patients with CSA, so the present study investigated the role of NO in forearm resistance vessels in such patients. The responses of forearm blood flow to acetylcholine (ACh; 8-24 μg/min) and sodium nitroprusside (SNP; 0.4-1.2 μg/ml) infusions was examined using plethysmography, and subsequently the responses to ACh after an infusion of NG-monomethyl-L-arginine (L-NMMA; 4 μmol/min, for 5 min) in 17 patients with CSA and 17 age- and sex- matched controls. The vasodilator responses to ACh and SNP were comparable between the 2 groups (p=NS). L-NMMA significantly suppressed the vasodilator responses to ACh in controls (p<0.05), but there was no significant difference in the responses to ACh before and after infusion of L-NMMA in patients with CSA (p=NS). These results indicate that endothelial NO-mediated vasodilatation is decreased in the forearm resistance vessels of patients with CSA. (Jpn Circ J 2001; 65: 81 - 86)

Copyright © 2001 THE JAPANESE CIRCULATION SOCIETY

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