SICE Journal of Control, Measurement, and System Integration
Online ISSN : 1884-9970
Print ISSN : 1882-4889
ISSN-L : 1882-4889
Special Issue: Frontiers in Life Engineering
Mathematical Model of Glucose-Insulin Metabolism in Type 1 Diabetes Including Digestion and Absorption of Carbohydrates
Claudia Cecilia YAMAMOTO NOGUCHIEiko FURUTANIShoichiro SUMI
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2014 Volume 7 Issue 6 Pages 314-320

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Abstract

The authors propose a mathematical model of glucose-insulin metabolism in type 1 diabetes based on Bergman and Shimoda insulin models, which are adjusted to represent diabetic state and improve the accuracy of subcutaneous insulin absorption, respectively. The authors also propose a model of digestion and absorption from carbohydrates based on the glycemic index (GI) of foods and carbohydrate bioavailability concepts that provide a glucose-equivalent representation of the impact of carbohydrates on blood glucose levels. Comparison with clinical data demonstrates that the proposed model is able to represent postprandial blood glucose excursion for carbohydrates with varying GI values.

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© 2014 The Society of Instrument and Control Engineers
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