2018 Volume 27 Issue 6 Pages 470-476
Glomangiopericytoma (GPC) is a rare tumor that occurs in the sinonasal tract. The authors report a case of a huge dumbbell-shaped GPC.
A 51-year-old woman with a two-year history of anosmia was referred to our hospital. Contrast-enhanced magnetic resonance imaging showed a tumor occupying the anterior cranial fossa and the nasal cavity. The preoperative diagnosis was olfactory neuroblastoma ; however, this could not be confirmed by a trans-nasal biopsy. The tumor was removed with combined endonasal and transcranial surgery following embolization of the feeding arteries. Hematoxylin and eosin staining revealed a hemangiopericytoma-pattern. Immunohistochemical staining showed that the tumor was positive for α-smooth muscle actin (α-SMA) and negative for S-100 protein, neuron specific enolase (NSE), signal transducer and activator of transcription 6 (STAT6), CD34 and epithelial membrane antigen (EMA), leading to the final diagnosis of GPC. The patient’s postoperative course was uneventful and stereotactic radiotherapy was performed to prevent recurrence.
GPC should be included in the differential diagnosis of tumors at the anterior skull base with intracranial and extracranial extension.
