Neurofibroma of the large intestine is very rare. None of the cases could not be found in these ten years in Japanese literature. It reveals no symptomes in early stage but later occur bleeding, anemia, abdominal pain and other symptomes. Roentogenogram and endoscopy are usually rather difficult to dignose it correctly. It is definitely diagnosed only by histological examination. Differential diagnosis between neurofibroma and other neurogenic or myogenic tumors is sometimes difficult. Alcian blue, Azan and Masson stain are used effectively in these cases. Electron microscopy is also useful to differentiate neurofibroma from Schwannoma. Surgical excision is the treatment of choice. Prognosis of the excision is good. Malignant change rarely occurs in a solitary neurofibroma. 10-20% of the neurofibroma associated with neurofibromatosis (von Recklinghausen) become malignant.
A case of the cecal neurofibroma of 57-year-old male was also reported in this paper.