1990 Volume 43 Issue 7 Pages 1379-1383
A 49-year-old man was admitted on November 15, 1988 with a 12-month history of painful bleeding from a rapidly growing perianal tumor. Physical examination revealed a 12.0 × 9.5-cm infected, friable, cauliflower-like tumor surrounding, the anal orifice. Histological examination of a biopsy specimen of the tumor confirmed the diagnosis of giant condyloma acuminatum (GCA) or verrucous carcinoma of the perineal region (Buschke-Loewenstein tumor). An abdominoperineal resection with clearance of the bilateral inguinal lymph nodes was performed on November 28, 1988. Microscopic study of the obtained specimen revealed marked papillomatosis, hyperkeratosis, and acanthosis of the epidermal cells. The mitotic activity was prominent and individual cell keratinization was seen. But the basement membrane was intact, polarity was preseved, and lymphatic invasion or lymphnode metastasis was negative. At the present time, 13 months following surgery, the patient is doing well without any evidence of tumor recurrence. In the present paper, we describe the clinicopathological features of GCA and the therapeutic aspects are discussed on the basis of the literature.
