（c）応用指向型研究
膜タンパク質結晶構造解析と創薬への可能性
－神経伝達物質トランスポーターホモログLeuTを例に－
2010 年 52 巻 1 号 p. 76-80
詳細
2010 年 52 巻 1 号 p. 76-80
Structure-based drug design for membrane proteins is far behind that for soluble proteins due to difficulty in crystallographic structure determination, despite the fact that about 60% of FDA-approved drugs target membrane proteins located at the cell surface. Stable homologs for a membrane protein of interest, such as prokaryotic neurotransmitter transporter homolog LeuT, might enable cooperative analyses by crystallography and functional assays, provide useful information for functional mechanisms, and thus serve as important probes for drug design based on mechanisms as well as structures.
