2015 年 57 巻 5 号 p. 304-309
Synapse formation is triggered through trans-synaptic interactions between selective pairs of pre- and postsynaptic adhesion molecules. Receptor tyrosine phosphatases (RPTP) can selectively interact with various postsynaptic adhesion molecules in a splicing-dependent manner. Here, we present our recent structural studies for the splicing-dependent regulation of the interactions between PTPδ and Interleukin-1 receptor accessory protein (IL-1RAcP)/ IL-1RAcP like 1 (IL1RAPL1).