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日本結晶学会誌
Vol. 59 (2017) No. 2-3 p. 96-101

記事言語:

http://doi.org/10.5940/jcrsj.59.96

最近の研究から

Pheganomycins(PGMs)derived from Streptomyces cirratus are one of the peptide antibiotics and synthesized under the cooperation of a novel peptide ligase, PGM1, and ribosome, in contrast of typical peptide antibiotics. In the biosynthesis, PGM1, which is a peptide ligase with broad substrate permissivity, can catalyze the linkage between several types of nonproteinogenic amino acid including a 2-guanidino group and some ribosomal peptides to generate N-terminal capping peptide. Herein, I present structural studies for the recognition mechanisms of N-terminal capping substrates and C-terminal ribosomal peptides.

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