日本結晶学会誌
Online ISSN : 1884-5576
Print ISSN : 0369-4585
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リボソーム由来ペプチドのN末端をキャッピングする新規ペプチドリガーゼの構造基盤
松井 崇
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ジャーナル フリー

2017 年 59 巻 2-3 号 p. 96-101

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Pheganomycins(PGMs)derived from Streptomyces cirratus are one of the peptide antibiotics and synthesized under the cooperation of a novel peptide ligase, PGM1, and ribosome, in contrast of typical peptide antibiotics. In the biosynthesis, PGM1, which is a peptide ligase with broad substrate permissivity, can catalyze the linkage between several types of nonproteinogenic amino acid including a 2-guanidino group and some ribosomal peptides to generate N-terminal capping peptide. Herein, I present structural studies for the recognition mechanisms of N-terminal capping substrates and C-terminal ribosomal peptides.

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