ミニ特集 核酸構造研究の新展開
LysRタイプ転写調節因子CbnRのDNA結合ドメインとDNAとの複合体構造
2018 年 60 巻 2-3 号 p. 135-141
詳細
2018 年 60 巻 2-3 号 p. 135-141
LysR-type transcriptional regulators（LTTRs）are one of the most abundant transcriptional regulators in bacteria. CbnR derived from Cupriavidus necator NH9 is an LTTR involved in transcriptional activation of the cbnABCD genes that encode chlorocatechol degradative enzymes. The crystal structure of the DNA binding domain of CbnR（CbnR_DBD）in complex with recognition binding site（RBS）of the cbnA promoter showed details of interaction between the CbnR_DBD and RBS. We analyzed the sequence selectivity of CbnR by comparison of the CbnR_DBD-RBS and the BenM_DBD-RBS complexes.
