連載企画 X線結晶学者のためのクライオ電子顕微鏡解析の手引き
クライオ電子顕微鏡による二成分毒素の構造解析：
トキシン膜透過システムの構造基盤
2022 年 64 巻 1 号 p. 69-76
詳細
2022 年 64 巻 1 号 p. 69-76
The iota toxin produced by Clostridium perfringens type E is a binary toxin comprising two independent polypeptides：Ia, an ADP-ribosyltransferase, and Ib, which is involved in cell binding and translocation of Ia across the cell membrane. Binary toxin family includes C. perfringens iota toxin, C. difficile CDT, C. spiroforme CST, C. botulinum C2, and B. anthracis anthrax toxin. Here we introduce the binary toxin complex structures using single-particle Cryo-EM structural analysis and the structural basis of toxin translocation system.
