Special Issue New Approaches for Structural Biology
Conformational State Estimation of Biological Macromolecules in Solution using BioSAXS
2023 Volume 65 Issue 1 Pages 42-50
Details
2023 Volume 65 Issue 1 Pages 42-50
Small-angle X-ray scattering（SAXS）for solution samples of biological macromolecules, recently called BioSAXS, has been used to estimate the conformational state of flexible proteins and unstable protein complexes in solution. With the advent of a new technique called SEC-SAXS, it has become easier to obtain structural information derived only from the target molecule, and it is now possible to estimate the structural state in solution with higher accuracy than 10 years ago. In this article, I will introduce not only some characteristic examples of BioSAXS analysis, but also the recently developing technique of time-resolved measurement.
